Figure 3.

Simulated signal intensities and assigned amino acid-associated weights are recovered by an amino acid composition-based regression model. (A) Simulated signal intensities (<a onClick="popup('http://www.biomedcentral.com/1471-2164/13/79/mathml/M17','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/13/79/mathml/M17">View MathML</a>) obtained by amino acid position-dependent simulation of the binding of 150 antibodies to an array of 255 14-mer peptides were predicted using the regression model given by Equation 1. This regression model takes into account only the amino acid composition of the simulated peptide sequences. Predictive performance: Q2 = 0.40. Simulated signal intensities were computed using Equation 2. (B) Equation 1 was used to estimate (<a onClick="popup('http://www.biomedcentral.com/1471-2164/13/79/mathml/M18','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/13/79/mathml/M18">View MathML</a>), which are shown against the assigned AAWS (<a onClick="popup('http://www.biomedcentral.com/1471-2164/13/79/mathml/M8','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/13/79/mathml/M8">View MathML</a>) used to generate the simulated signal intensities <a onClick="popup('http://www.biomedcentral.com/1471-2164/13/79/mathml/M17','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/13/79/mathml/M17">View MathML</a>. Coefficient of correlation: r = 0.92.

Greiff et al. BMC Genomics 2012 13:79   doi:10.1186/1471-2164-13-79
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