Figure 3.

The diagram shows known binary protein-protein interactions between the molecular chaperone and ubiquitin-related overlapping regulators in Table 2. The interactions are included if they were identified between orthologues of the proteins from any species and are shown labelled with the names of the human orthologues with those involved in protein folding (chaperones) in blue and those in ubiquitin-related pathways in red. The human orthologues and their corresponding C. elegans orthologues are as follows: HSF1, hsf-1; Hsc70, hsp-1; DnaJB5, dnj-13; CHIP, chn-1; p97, cdc-48.1; Ube2D2, let-70.