Table 1

Simulation analysis to explore the target-recognition preference of CNV-miRNAs and non-CNV-miRNAs
The numberof regulatory miRNAs Mean of 1,000 simulations Std. dev of 1,000 simulations Observed number p-values
Genes regulated exclusively by CNV miRNAs 1 CNV-miRNA 716.479 67.633 823 0.0576
2 CNV-miRNAs 134.428 22.810 211 0.000392
3 CNV-miRNAs 28.597 8.115 67 0.000001
4 CNV-miRNAs 7.119 3.421 22 0.000006
5 CNV-miRNAs 2.809 1.846 11 0.0000004
Genes regulated exclusively by non-CNV miRNAs 1 non-CNV-miRNA 1514.503 67.633 1,408 0.0576
2 non-CNV-miRNAs 609.760 45.420 515 0.0184
3 non-CNV-miRNAs 277.837 31.374 207 0.0119
4 non-CNV-miRNAs 145.793 22.981 95 0.0135
5 non-CNV-miRNAs 185.483 42.717 105 0.0297

The p-values were obtained from the Z-score, which was calculated as (observed number – mean number of 1000 simulations) / standard deviation of 1000 simulations.

Wu et al.

Wu et al. BMC Genomics 2012 13:707   doi:10.1186/1471-2164-13-707

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