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Open Access Highly Accessed Research article

ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells

Andreas Jeron12*, Wiebke Hansen3, Franziska Ewert2, Jan Buer3, Robert Geffers4* and Dunja Bruder12

Author Affiliations

1 Immune Regulation group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, Braunschweig, 38124, Germany

2 Infection Immunology group, Institute of Medical Microbiology, Faculty of Medicine, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, Magdeburg, 39120, Germany

3 Institute of Medical Microbiology, University Hospital Essen, Hufelandstraße 55, Essen, 45122, Germany

4 Genome Analytics group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, Braunschweig, 38124, Germany

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BMC Genomics 2012, 13:705  doi:10.1186/1471-2164-13-705

Published: 17 December 2012

Additional files

Additional File 1:

Identified FOXP3 ChIP-regions. List of all identified FOXP3 ChIP regions in resting and PMA/ionomycin-stimulated FOXP3-over-expressing Jurkat T cells including chromosomal coordinates, a visual representation map of their chromosomal distribution and their genomic annotation according to the Genomic Position Annotation Tool.

Format: XLSX Size: 919KB Download file

Open Data

Additional File 2:

GeneGO pathway analysis of FOXP3-bound genes. Analysis of annotated FOXP3 ChIP hits for statistically over-represented pathways.

Format: PDF Size: 19KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional File 3:

Expression microarray data. List of 410 transcripts responding to FOXP3-over-expression in Jurkat T cells under resting and PMA/ionomycin-stimulated conditions.

Format: XLSX Size: 103KB Download file

Open Data

Additional File 4:

Comparison of human FOXP3-ChIP studies. Table containing comparison of identified FOXP3 ChIP hits with previously published human FOXP3-ChIP data.

Format: XLSX Size: 417KB Download file

Open Data