Table 2

Mechanistic responses in Atlantic cod larvae exposed to chemically (CD) or mechanically (MD) dispersed oil droplets for four days
Group Name p-value Ratio Group Name p-value Ratio
CDH Positive Acute Phase Response Proteins 5.1E-05 6/30 (0.2) MDH Negative Acute Phase Response Proteins 2.07E-05 5/8 (0.625)
CDH Aryl Hydrocarbon Receptor Signaling 2.66E-04 12/157 (0.076) MDH p53 Signaling 4.86E-04 14/95 (0.147)
CDH Cell Cycle: G1/S Checkpoint Regulation 3.04E-04 7/57 (0.123) MDH Liver Proliferation 7.01E-04 17/133 (0.128)
CDH Negative Acute Phase Response Proteins 6.08E-04 3/8 (0.375) MDH Oxidative Stress 7.68E-04 10/57 (0.175)
CDH Fatty Acid Metabolism 2.06E-03 9/123 (0.073) MDH Cholesterol Biosynthesis 1.13E-03 5/16 (0.312)
CDM FXR/RXR Activation 3.6E-07 6/87 (0.069) MDM Aryl Hydrocarbon Receptor Signaling 4 6.02E-04 5/157 (0.032)
CDM LXR/RXR Activation 2.28E-06 6/119 (0.05) MDM Xenobiotic Metabolism Signaling 7.95E-04 7/349 (0.02)
CDM Positive Acute Phase Response Proteins 2.52E-06 4/30 (0.133) MDM Cytochrome P450 Panel - Substrate is a Xenobiotic (Human) 2.71E-03 2/18 (0.111)
CDM Fatty Acid Metabolism 6.67E-04 4/123 (0.033) MDM NRF2-mediated Oxidative Stress Response 3.69E-03 5/237 (0.021)
CDM Xenobiotic Metabolism Signaling 8.92E-04 6/349 (0.017)
MDL Negative Acute Phase Response Proteins 3.6E-05 2/8 (0.25)
MDL Decreases Respiration of Mitochondria 7.05E-05 2/11 (0.182)
MDL LXR/RXR Activation 3.42E-04 3/119 (0.025)
MDL TR/RXR Activation 4.45E-03 2/86 (0.023)

IPA Tox lists with significant responses H = high concentration M = medium concentration L = low concentration.

Olsvik et al.

Olsvik et al. BMC Genomics 2012 13:702   doi:10.1186/1471-2164-13-702

Open Data