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Open Access Highly Accessed Open Badges Research article

Is chemically dispersed oil more toxic to Atlantic cod (Gadus morhua) larvae than mechanically dispersed oil? A transcriptional evaluation

Pål A Olsvik1*, Kai K Lie1, Trond Nordtug2 and Bjørn Henrik Hansen2

Author Affiliations

1 National Institute of Nutrition and Seafood Research, Nordnesboder 1-2, Bergen, N-5005, Norway

2 SINTEF, Materials and Chemistry, Marine Environmental Technology, Trondheim, N-7465, Norway

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BMC Genomics 2012, 13:702  doi:10.1186/1471-2164-13-702

Published: 14 December 2012

Additional files

Additional file 1:

Concentrations (in μg/L) of ∑ PAHs in the exposure media during the experiment. Values are given as average ± standard deviation (N=8).

Format: XLSX Size: 40KB Download file

Open Data

Additional file 2:

ANOVA generated gene lists. Gene lists generated with ANOVA analysis from the six groups of larvae (CDH, CDM, CDL, MDH, MDM and MDL), with sequence IDs, sequence descriptions, gene names used for functional analysis, P-values and fold changes. ANOVA. P<0.05.

Format: XLSX Size: 171KB Download file

Open Data

Additional file 3:

Top ranked gene sets. Top ranked gene sets in larvae from all exposure groups compared to the control group, as analyzed with Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA). Annotations as of June 2011.

Format: XLSX Size: 24KB Download file

Open Data

Additional file 4:

Top affected IPA networks. Top affected IPA Core Analyses networks in the cod larvae exposed to the highest concentration of chemically dispersed oil (CDH group) and mechanically dispersed oil (MDH). All molecules in each group included.

Format: XLSX Size: 27KB Download file

Open Data

Additional file 5:

IPA Compare networks. In an attempt to identify unique and common molecules across the gene lists the IPA-Compare function was applied. Additional file 5 shows the associated functions of the top networks as suggested by IPA Core Analysis in significantly affected transcripts in cod larvae exposed to the different exposure treatments. Only molecules uniquely affected in each group included.

Format: XLSX Size: 28KB Download file

Open Data