Typical completion patterns to the KEGG modules by 768 prokaryotic species.A: universal modules. (A-1) The modules completed by more than 70% of 768 prokaryotic species. M00018_1, which is threonine biosynthesis (aspartate homoserine threonine) is one of examples of the pattern A-1. (A-2) The modules for which more than 70% of 768 prokaryotic species show a module completion ratio of >80%. M00019_1, which is leucine biosynthesis (pyruvate 2-oxoisovalerate leucine) is one of examples of the pattern A-2. B: Restricted modules completed by less than 30% of 768 prokaryotic species. M00038_1, which is tryptophan metabolism (tryptophan kynurenine 2-aminomuconate) is one of examples of the pattern B. C: Diversified modules. These are the modules that vary in the module completion ratio among 768 prokaryotic species. M00012_1, which is glyoxylate cycle is one of examples of the pattern C. D: Non-prokaryotic modules completed by no prokaryotic species. M00014_1, which is glucuronate pathway (uronate pathway) is one of examples of the pattern D. Breakdown of taxonomic variations that complete each KEGG module is summarized in Table 1 and shown in Supplementary Table S2 in detail.
Takami et al. BMC Genomics 2012 13:699 doi:10.1186/1471-2164-13-699