Correlation patterns of allele-specificity among different TFs and HMs in GM12878 cells discovered by iASeq. (a) The BIC values for different class number K. The BIC achieves the minimum at K=2. (b) The estimated V and W when K=2. Each row corresponds to a class. Each column represents a dataset. The color in the cell (k,d) represents the SR or SN probability in class k and dataset d. From white to dark, the probability increases from 0 to 1. The bar plot and the numbers shown under Πare the estimated number of SNPs in each class (i.e., the total number of SNPs). The bar plot and the numbers shown under aiare the number of SNPs identified for the corresponding class using the posterior probability Pr(ai=k|Xi,Ni,Π,V,W)>0.9 as cutoff. (c) A closer look at V and W in a number of representative datasets. The barplots show the estimated SR and SN probabilities vkdand wkdin a number of selected datasets. Left: the skewing probabilities in class 1. Right: the skewing probabilities in class 2. The height of each bar represents the SR or SN probability.
Wei et al. BMC Genomics 2012 13:681 doi:10.1186/1471-2164-13-681