Table 1

Enriched molecular functions of compared Drosophila melanogaster maternal genes
Group GO term P-value Sample frequency Background frequency
A small molecule binding (GO:0036094) 5.17e-08 525/3235 (16.2%) 552/3718 (14.8%)
nucleoside phosphate binding (GO:1901265) 1.24e-07 486/3235 (15.0%) 510/3718 (13.7%)
nucleotide binding (GO:0000166) 1.24e-07 486/3235 (15.0%) 510/3718 (13.7%)
organic cyclic compound binding (GO:0097159) 1.24e-07 486/3235 (15.0%) 510/3718 (13.7%)
B sequence-specific DNA binding transcription factor activity (GO:0003700) 5.44e-04 35/184 (19.0%) 290/3718 (7.8%)
nucleic acid binding transcription factor activity (GO:0001071) 5.44e-04 35/184 (19.0%) 290/3718 (7.8%)
structural constituent of chitin-based cuticle (GO:0005214) 4.36e-03 11/184 (6.0%) 41/3718 (1.1%)
structural constituent of cuticle (GO:0042302) 7.28e-03 11/184 (6.0%) 43/3718 (1.2%)
C endopeptidase activity (GO:0004175) 6.26e-10 37/299 (12.4%) 124/3718 (3.3%)
serine-type endopeptidase activity (GO:0004252) 5.99e-09 21/299 (7.0%) 45/3718 (1.2%)
peptidase activity, acting on L-amino acid peptides (GO:0070011) 8.20e-08 41/299 (13.7%) 171/3718 (4.6%)
serine-type peptidase activity (GO:0008236) 4.22e-07 21/299 (7.0%) 54/3718 (1.5%)

The four enriched molecular function terms with the lowest p-values for each group within the comparison of the Berkeley Drosophila Genome Project in situ database maternal genes to the T. castaneum findings. Group A consists of D. melanogaster maternal genes with T castaneum maternally loaded orthologs. Group B consists of D. melanogaster maternal genes with T. castaneum orthologs which were expressed in fertilized eggs but not maternally loaded. Group C consists of Drosophila melanogaster maternal genes with T. castaneum orthologs which were not expressed in eggs.

Preuss et al.

Preuss et al. BMC Genomics 2012 13:671   doi:10.1186/1471-2164-13-671

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