Table 2

Similarities between yeast and human SCD proteins
Selection of yeast SCD genes with human ortholog SCD genes
Yeast Human Function
Dna2* (DNA2) Nuclease and helicase required for Okazaki fragment processing; involved in DNA repair.
Fkh2 (FOXJ3) Transcription factor with a major role in the expression of G2/M phase genes.
Gcn2* (EIF2AK4) Protein kinase, phosphorylates eIF2 (Sui2p) in response to starvation; contributes to DNA damage checkpoint control.
Pol5 (MYBBP1A) DNA Polymerase phi; not required for chromosomal DNA replication; required for the synthesis of rRNA.
Nup100/116 (POM121) Subunit of the nuclear pore complex (NPC); interacts with mRNA export factor Mex67p and with Kap95p.
Rad54* (RAD54L) Involved in the recombinational repair of double-strand breaks.
Rfx1 (RFX1) Major transcriptional repressor of DNA-damage-regulated genes.
Smc2 (SMC2) Subunit of the condensin complex.
Taf9** (TAF9B) Subunit of TFIID and SAGA complexes.
Tif4631* (EIF4G2) Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F).
Selection of yeast SCD genes whose human ortholog contains phosphorylated S/T-Q sites
Bub1 (BUB1) Protein kinase that play crucial roles in the Spindle Assembly Checkpoint.
Cdc20 (CDC20) Cell-cycle regulated activator of APC/C, which is required for metaphase/anaphase transition.
Cdc4 (FBXW7) F-box protein that controls cell cycle function, sulfur metabolism, and methionine biosynthesis.
Hrr25 (CSNK1D) Protein kinase involved in regulating vesicular trafficking, DNA repair, and chromosome segregation.
Mad1 (MAD1) Coiled-coil protein involved in the spindle-assembly checkpoint.
Mcm1 (SRF) Transcription factor involved in cell-type-specific transcription and pheromone response.
Mcm6 (MCM6) Protein involved in DNA replication; component of the Mcm2-7 hexameric pre-replicative complex.
Mih1* (CDC25A) Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p.
Mlh1** (MLH1) Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis.
Msh3 (MSH3) Mismatch repair protein.
Pds5** (APRIN) Protein required for establishment and maintenance of sister chromatid condensation and cohesion.
Sch9 (RPS6KA1) Kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression.
Tid3** (NDC80) Part of the kinetochore-associated Ndc80 complex involved in chromosome segregation.
Ubr1 (UBR1) E3 ubiquitin ligase (N-recognin) that ubiquitinate substrates in the N-end rule pathway.
Ycs4** (NCAPD2) Subunit of the condensin complex.
Selection of yeast SCD genes whose human ortholog contains an SCD and is known to be phosphorylated in S/T-Q sites
Akl1* (AAK1) Protein kinase involved in endocytosis and actin cytoskeleton organization.
Bni1 (FMN2) Formin, nucleates the formation of linear actin filaments; involved in and mitotic spindle orientation.
Cdc3** (SEP6*) Component of the septin ring of the mother-bud neck that is required for cytokinesis.
Ctf18** (CHTF18) Required for sister chromatid cohesion; part of the DNA damage replication checkpoint.
Exo1 (EXO1*) 5-3 exonuclease and flap-endonuclease involved in recombination, DSB and mismatch repair.
Pol2 (POLE) Catalytic subunit of DNA polymerase (II) epsilon.
Rad50* (RAD50*) Subunit of MRX complex involved in processing double-strand DNA breaks, and telomere maintenance.
Rts1 (PPP2RA*) Regulatory subunit of protein phosphatase 2A (PP2A).
Tom1** (HUWE1*) E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus.

* Phosphorylated in S/T-Q sites in mass spectrometry searches.

** Phosphorylated in S/T-Q sites within an SCD in mass spectrometry searches.

Cheung et al.

Cheung et al. BMC Genomics 2012 13:664   doi:10.1186/1471-2164-13-664

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