Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster
- Equal contributors
1 Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
2 Laboratory of Systems Genetics, National Heart Lung and Blood Institute, Bethesda, MD, 20892-1654, USA
3 Department of Genetics, North Carolina State University, Raleigh, NC, 27695, USA
4 Present address: Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA
BMC Genomics 2012, 13:659 doi:10.1186/1471-2164-13-659Published: 22 November 2012
Additional file 1:
Variation in mitochondrial protein density among eight of the 40D. melanogasterDGRP wild-derived inbred lines. This file includes the distribution of line means for mitochondrial protein density in eight of the 40 DGRP lines and scatter plots of correlations between mitochondrial traits.
Format: DOCX Size: 34KB Download file
Additional file 2:
List of SNPs significantly correlated with mitochondrial respiration and coupling efficiency in the analyses averaged across sexes (Panel A) and stratified by sex (Panel B). This file includes SNP position, FlyBase accession number and name of the genes tagged by the SNPs and near intergenic SNPs, P-value from the ANOVA of the difference in trait means between the two SNP classes, minor allele frequency of the SNPs.
Format: XLSX Size: 53KB Download file
Additional file 3:
List of transcripts significantly correlated with mitochondrial respiration and coupling efficiency. This file includes Affymetrix Probe identification number, FlyBase accession number and name of the gene transcript, P-value from the regression analyses, and gene ontology information.
Format: XLSX Size: 54KB Download file
Additional file 4:
Modules of correlated transcripts associated with mitochondrial function. This file shows the average correlation of a transcript with all other transcripts in its module (degree) and the average correlation of all transcripts in the module (average degree). (XLSX 31 kb)
Format: XLSX Size: 31KB Download file
Additional file 5:
Nucleotide sequence of primers used for qRT-PCRs. This file reports the gene symbol, direction of the primer, and nucleotide sequence. (DOCX 11 kb)
Format: DOCX Size: 12KB Download file