Table 5

Top GO enrichment terms for methylation modules
Module Size Rank p.Bonf Fraction Ontology Term name
32 1067 1 4.20E-09 0.1875 CC extracellular region
1 1045 1 8.20E-16 0.790123 CC intracellular
1 1045 3 1.50E-11 0.083333 CC ribonucleoprotein complex
30 616 1 2.50E-21 0.34687 BP anatomical structure development
30 616 2 1.60E-18 0.189509 BP nervous system development
7 594 1 8.30E-10 0.157424 BP immune system process
7 594 2 9.10E-10 0.177102 MF receptor activity
3 427 1 3.20E-12 0.259947 CC extracellular region
12 130 1 0.0032 0.075 BP DNA recombination
2 105 1 1.70E-10 0.191919 BP lymphocyte activation
2 105 2 2.30E-10 0.20202 BP leukocyte activation
2 105 3 3.60E-10 0.323232 BP immune system process

For each module we list the top enriched GO terms. Columns list the module label, module size, rank of the enrichment p-value for that particular module, the Bonferroni-corrected enrichment p-value (the correction is performed with respect to the number of GO terms), fraction of the module genes also in the GO term, GO ontology, and GO term name. Multiple methylation modules exhibit significant enrichment. Row shading separates modules for easier reading. Again, the enrichment provides evidence that the modules are biologically meaningful.

van Eijk et al.

van Eijk et al. BMC Genomics 2012 13:636   doi:10.1186/1471-2164-13-636

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