Table 1
List of all the aminoacyl tRNA synthetases and their associated proteins, aaRS paralogs and editing domains with their CDD domain assignments and subcellular localization
Gene name Length (aa) HMM based function assignment E-value# Swissprot function assignment Subcellular location (PSORT II) CDD based domain assignment
CLASS I aaRS LmjF.12.0250 784 Cysteinyl-tRNA synthetase 1.00E-191 Cysteinyl-tRNA synthetase Cytosol CysRS_Core; anticodon_la_like_superfamily
LmjF.15.1440 570 Glutaminyl-tRNA synthetase 8.70E-208 Glutaminyl-tRNA synthetase Cytosol GlnRS_core; GlnRS_core; tRNA_synt_Ic_C_superfamily
LmjF.30.3240 594 Glutaminyl-tRNA synthetase 7.00E-079 Glutaminyl-tRNA synthetase Cytosol GlnRS_core; GlnRS_core; tRNA_synt_Ic_C_superfamily
LmjF.27.1310 692 Arginyl-tRNA synthetase 2.00E-151 Arginyl-tRNA synthetase Cytosol Arg_tRNA_synt_N; ArgRS_Core; anticodon_Ia_like_superfamily
LmjF.36.5620 1009 Isoleucyl-tRNA synthetase 0 Isoleucyl-tRNA synthetase Cytosol IleRS_Core; Anticodon_Ia_like_superfamily
LmjF.13.1100 1075 Leucyl-tRNA synthetase 3.70E-140 Leucyl-tRNA synthetase Cytosol IleRS_Core; Anticodon_Ia_like_superfamily
LmjF.21.0810* 747 Methionyl-tRNA synthetase 6.00E-145 Methionyl-tRNA synthetase Cytosol MetRS_Core_superfamily; Anticodon_Ia_Met
LmjF.23.0300 412 Tryptophanyl-tRNA synthetase 1.90E-062 Tryptophanyl-tRNA synthetase Cytosol TrpRS_core
LmjF.29.0060 480 Tryptophanyl-tRNA synthetase 1.70E-095 Tryptophanyl-tRNA synthetase Mitochondrial TrpRS_core
LmjF.14.1370* 682 Tyrosyl-tRNA synthetase 1.10E-051 Tyrosyl-tRNA synthetase Endoplasmic reticulum TyrRS_core; TyrRS_core
LmjF.30.3130 967 Valyl-tRNA synthetase 0 Valyl-tRNA synthetase Cytosol ValRS_core; anticodon_Ia_Val; Val_tRNA_synt_C_superfamily
CLASS II aaRS LmjF.22.1540 962 Alanyl-tRNA synthetase 3.10E-262 Alanyl-tRNA synthetase Cytosol AlaRS_core; tRNA_SAD
LmjF.30.0460 550 Aspartyl-tRNA synthetase 3.90E-106 Aspartyl-tRNA synthetase Cytosol AspRS_cyto_N; AsxRS_Core
LmjF.21.0895 641 Aspartyl-tRNA synthetase 5.70E-097 Aspartyl-tRNA synthetase Mitochondrial AspRS_cyto_N; ClassII_aaRS_like_core_superfamily; ClassII_aaRS_like_core_superfamily
LmjF.34.2340 890 Asparaginyl-tRNA synthetase 2.40E-144 Asparaginyl-tRNA synthetase Cytosol tRNA_synt_Ic_R1_superfamily; AsnRS_cyto_like_N; AsxRS_core
LmjF.36.3840 628 Glycyl-tRNA synthetase 5.10E-056 Glycyl-tRNA synthetase Cytosol GlyRS_core; HGTP_anticodon
LmjF.30.0130 586 Lysyl-tRNA synthetase 8.20E-184 Lysyl-tRNA synthetase Cytosol LysRS_N; LysRS_Core
LmjF.15.0230 536 Lysyl-tRNA synthetase 9.30E-148 Lysyl-tRNA synthetase Cytosol LysRS_N; LysRS_Core
LmjF.19.1040 633 Phenylalanyl-tRNA synthetase 3.20E-053 Phenylalanyl-tRNA synthetase Cytosol B3_4_superfamily; B5_superfamily; PheRS_beta_core
LmjF.32.0870 499 Phenylalanyl-tRNA synthetase 5.90E-052 Phenylalanyl-tRNA synthetase Cytosol PheRS_alpha_core
LmjF.18.1210 731 Prolyl-tRNA synthetase 1.30E-188 Prolyl-tRNA synthetase Cytosol Ybak_like_superfamily; ProRS_arch_euk; HGTP_anticodon_superfamily
LmjF.18.1220 731 Prolyl-tRNA synthetase 1.20E-190 Prolyl-tRNA synthetase Cytosol Ybak_like_superfamily; ProRS_arch_euk; HGTP_anticodon_superfamily
LmjF.11.0100 474 Seryl-tRNA synthetase 4.40E-135 Seryl-tRNA synthetase Cytosol Seryl_tRNA_N_superfamily; SerRS_Core
LmjF.30.0630 473 Histidyl-tRNA synthetase 2.30E-103 Histidyl-tRNA synthetase Cytosol HisRS_Core; HisRS_anticodon
LmjF.35.1410 787 Threonyl-tRNA synthetase 3.20E-252 Threonyl-tRNA synthetase Cytosol TGS_superfamily; tRNA_SAD; ThrRS_Core; HGTP_anticodon
Non-canonical LmjF.09.0950 595 O-Phosphoseryl-tRNA Selenium transferase 9.10E-127 SLA/LP autoantigen-like protein Nuclear Selenium_SpcS
aaRS associated proteins LmjF.22.0470 426 EMAP-II like 1.20E-023 Hypothetical, Conserved Extracellular tRNA_binding_domain_superfamily
LmjF.16.1130 180 EMAP-II like 1.20E-015 Tyrosyl/methionyl-tRNA synthetase Cytosol tRNAbindingdomain_superfamily
AsnRS paralog LmjF.26.0830 353 Asparagine Synthetase A 2.00E-002 Aspartate, ammonia ligase Mitochondrial ClassII_aaRS_like_core_superfamily
Trans Editing domains LmjF.15.0690 491 AlaX 3.90E-028 Hypothetical, conserved Cytosol tRNA_SAD_superfamily
LmjF.03.0710 253 YbaK 2.20E-002 Hypothetical, conserved Cytosol Ybak_like_superfamily
LmjF.21.0910 275 YbaK 7.20E-003 Hypothetical, conserved Cytosol Ybak_like_superfamily
LmjF.36.2730 152 Dtda 1.00E-026 D-tyrosine deacylase Cytosol Dtyr_deacylase
LmjF.34.3360* 211 Dtda 5.40E-020 Hypothetical, conserved Cytosol Dtyr_deacylase_superfamily

* indicates L. major sequences whose crystal structures are available # E-value (Expectation value) is an indication of the significance of a hit to the HMM Model queried. This gives a more quantitative measure of statistical significance. The lower the E-value, the better is the significance of the hit to the query HMM.

Gowri et al. BMC Genomics 2012 13:621   doi:10.1186/1471-2164-13-621

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