Open Access Highly Accessed Research article

Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome

Björn Reinius123*, Martin M Johansson1, Katarzyna J Radomska1, Edward H Morrow4, Gaurav K Pandey5, Chandrasekhar Kanduri6, Rickard Sandberg23, Robert W Williams7 and Elena Jazin1

Author Affiliations

1 Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden

2 Ludwig Institute for Cancer Research, Stockholm, Sweden

3 Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden

4 School of Life Sciences, University of Sussex, Brighton, United Kingdom

5 Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

6 Department of Medical and Clinical Genetics, Department of Biomedicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

7 Department of Anatomy and Neurobiology, University of Tennessee, Knoxville, USA

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BMC Genomics 2012, 13:607  doi:10.1186/1471-2164-13-607

Published: 10 November 2012

Additional files

Additional file 1:

Microarray results: genes on the X-chromosome. The table shows the statistics from the sex-specific analysis for probes mapping to the X-chromosome. “Biotype” is given according to Ensembl (BioMart:Ensembl Genes 62/NCBIM37), “Branch” according to Zhang et al. [28]. The colour code indicates the following significance: p<0.01; red: female-biased, blue: male-biased. This level of significance was marked to facilitate interpretation of the table, but note that the significance criterion used in the main study was p<0.001.

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Additional file 2:

Microarray results: all chromosomal locations. The table shows the statistics from the sex-specific analysis for all probes present on the Affymetrix mouse 430v.2 array. The colour code indicates the following significance: p<0.01; red: female-biased, blue: male-biased. This level of significance was marked to facilitate interpretation of the table, but note that the significance criterion used in the main study was p<0.001.

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Additional file 3:

A-E. Gene Ontology analysis. Results from a Gene Ontology analysis of female- and male-biased X-linked and autosomal genes, using DAVID Bioinformatics Resources 6.7, NIAID/NIH [26,27]. The GO analysis was performed using as reference either X-genes or all genes included in the microarray, as specified in the title of each table.

Format: XLS Size: 2.3MB Download file

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