Open Access Research article

Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. orientalis Toba04 gives novel insights into Francisella evolution and pathogenecity

Settu Sridhar1, Animesh Sharma1, Heidi Kongshaug2, Frank Nilsen2 and Inge Jonassen13*

Author Affiliations

1 Department of Informatics, University of Bergen, Bergen, Norway

2 Department of Biology, University of Bergen, Bergen, Norway

3 Computational Biology Unit, Uni computing, University of Bergen, Bergen, Norway

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BMC Genomics 2012, 13:598  doi:10.1186/1471-2164-13-598

Published: 6 November 2012

Additional files

Additional file 1:

Table S1.The table lists the unique proteins present in Francisella noatunensis subsp.orientalis Toba04 which might have transferred from other bacteria through horizontal gene transfer. Genes which has at least 50% alignment match to the original protein has been selected. Table S2: The table lists the unique proteins present in Francisella tularensis subspecies which might have transferred from other bacteria through horizontal gene transfer. Genes which has at least 50% alignment match to the original protein has been selected. Table S3: The table lists the proteins which are present uniquely in each Francisella tularensis subspecies. Where as in the subspecies column “H” means the protein is present in Francisella tularensis subsp. holarcticaOSU18, “M” means the protein is present in Francisella tularensis subsp. mediasiaticaFSC 147, and “T” means the protein is present in Francisella tularensis subsp. tularensis SCHU s4. Entries with multiple letters are present in multiple subspecies. Figure S1. Circular Genome view of Francisella noatunensis subsp.orientalisToba04.Figure 2. Map showing links between contigs. Figure 3. Result from DAVID server showing over representation of functional terms in metabolic competent species. Figure 4. The given figure is one part of the comparison of F. noatunensis subsp. orientalis Toba04 and F. philomiragia subsp. philomiragia ATCC 25017 metabolic pathway. Red colour indicates the reaction is shared between F. noatunensis subsp. orientalis and F. philomiragia subsp. philomiragia. Thin green lines indicates pathway hole in F. philomiragia subsp. philomiragia. Thick green line is the presence of reaction in F. philomiragia subsp. philomiragia.

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