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Open Access Highly Accessed Research article

Toward understanding the genetic basis of adaptation to high-elevation life in poikilothermic species: A comparative transcriptomic analysis of two ranid frogs, Rana chensinensis and R. kukunoris

Weizhao Yang12, Yin Qi1, Ke Bi3 and Jinzhong Fu14*

Author Affiliations

1 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China

2 Graduate University of Chinese Academy of Sciences, Beijing, 100049, China

3 Museum of Vertebrate Zoology, University of California, Berkeley, CA, 94720-3160, USA

4 Department of Integrative Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada

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BMC Genomics 2012, 13:588  doi:10.1186/1471-2164-13-588

Published: 1 November 2012

Additional files

Additional file 1:

Characteristics of gene annotation of assembled transcripts against the reference dataset. A. E-value distribution of blastx hits for each transcript with a cut-off E-value of 1E-5. B. Similarity distribution of blastx hits for each transcripts.

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Additional file 2:

Distribution of Gene Ontology (GO) categories (level 2) of transcripts for Rana chensinensis and R. kukunoris. The GO functional annotations are summarized in three main categories: cellular component, molecular function and biological process. The red bars and blue bars represent R. chensinensis and R. kukunoris, respectively. (PDF 240 kb)

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Additional file 3:

Average Ka/Ks ratio for each GO term. Only terms that have more than 10 orthologs are presented.

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Additional file 4:

Sampling sites and altitude distribution. Samples of Rana chensinensis were collected from Yaodu Township (105.45°E, 32.79°N) with an altitude of 604 m above sea level. Samples of R. kukunoris were collected from Zoige County (102.90°E, 33.58°N) with an altitude of 3,358 m above sea level.

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