Table 1

Prohormone and convertase genes identified across pig genome resources
Typea Symbol Gene name Genome sequenceb UniGenec UniProtd Genee
P ADM2 Intermedin complete Not Found F1RXU1 100517471
P ADM5 Adrenomedullin-5 complete Ssc.26627 A5LHG2 100101476
P ADML Adrenomedullin complete Ssc.314 P53366 397195
P ANF Atrial natriuretic factor complete Ssc.16245 P24259 397496
P ANFB Natriuretic peptide B complete Ssc.629 P07634 396844
P ANFC C-type natriuretic peptide complete Ssc.23867 P18104 493772
P APEL Apelin complete CU928865 Not Found 100625006
P AUGN Augurin complete Ssc.22487 F1SU23 100512958
P CALC Calcitonin/calcitonin gene-related peptide 1 complete Ssc.14052 A6P7L6 100125547
P CALCalt Preprocalcitonin gene-related peptide complete Ssc.56129 A6P7L7 100124407
P CART Cocaine- and amphetamine-regulated transcript protein complete Ssc.15900 Q307W6 397252
P CCKN Cholecystokinin complete Ssc.717 P01356 397468
P CMGA Chromogranin-A complete Ssc.4653 P04404 397540
P COLI Pro-opiomelanocortin complete Ssc.14556 P01192 396863
P CORT Cortistatin complete Not Found F1RIF7 100526112
P CRF Corticoliberin complete Ssc.69887 P06296 100127468
P CRSP1 Calcitonin receptor-stimulating peptide 1 complete Ssc.3741 Q862B1 396563
P CRSP2 Calcitonin receptor-stimulating peptide 2 complete Ssc.18558 Q766Y7 396574
P CRSP3 Calcitonin receptor-stimulating peptide 3 complete Ssc.17879 Q766Y6 396573
P CRSP3alt Calcitonin-2 complete Not Found A0A761 Not Found
P EDN1 Endothelin-1 complete Ssc.9364 P09558 396915
P EDN2 Endothelin-2 complete Not Found Not Found Not Found
P EDN3 Endothelin-3 complete Ssc.31972 A5A752 100049663
P GALA Galanin complete Ssc.713 P07480 397465
P GALP Galanin-like peptide complete Ssc.4875 Q9TT95 396772
P GAST Gastrin complete Ssc.644 P01351 445524
P GHRL Obestatin complete Ssc.440 Q9GKY5 396728
P GIP Gastric inhibitory polypeptide complete Ssc.38713 P01281 100621117
P GLUC Glucagon complete Ssc.17225 P01274 397595
P GON1 Progonadoliberin-1 complete Ssc.16310 P49921 397516
P GON2 Progonadoliberin-2 Not Found Not Found F1S8B1 100523475
P GRP Gastrin-releasing peptide complete Ssc.13923 P63153 Not Found
P HEPC Hepcidin complete Ssc.376 Q8MJ80 397207
P IAPP Islet amyloid polypeptide complete Ssc.8324 Q29119 100520838
P IGF1 Insulin-like growth factor 1 complete Ssc.16231 P16545 397491
P IGF2 Insulin-like growth factor 2 fragment Ssc.9365 P23695 396916
P INS Insulin complete Ssc.583 P01315 397415
P INSL3 Insulin-like 3 complete Ssc.11990 P51461 397024
P INSL5 Insulin-like 5 complete Not Found Not Found 100620109
P INSL6 Insulin-like 6 complete Ssc.46919 F1SK47 100158105
P KISS1 Metastasis-suppressor KiSS-1 complete Ssc.73565 B5M447 100145896
P MCH Pro-melanin-concentrating hormone complete Ssc.3287 Q9TTS8 396962
P MOTI Motilin complete Ssc.714 P01307 397466
P NEU1 Oxytocin complete Ssc.15668 P01177 100152272
P NEU2 Neurophysin-2 complete Ssc.4210 P01183 396995
P NEUT Neurotensin complete Ssc.38680 F1SPX3 100739079
P NMB Neuromedin-B complete Ssc.2083 B0LUW4 100141313
P NMS Neuromedin-S complete Ssc.12508 C3UZJ1 100294685
P NMU Neuromedin-U complete Ssc.12508 P34964 100523263
P NPB Neuropeptide B complete Ssc.82498 Not Found Not Found
P NPFF Neuropeptide FF complete Ssc.44958 F1SFP1 100518250
P NPS Neuropeptide S complete Ssc.73596 F1RSG4 100188981
P NPW Neuropeptide W complete Ssc.15796 Q8MI35 396680
P NPY Neuropeptide Y complete Ssc.15981 P01304 397304
P OREX Orexin complete Ssc.15983 O77668 397305
P OSTN Osteocrin (Musclin) complete Ssc.5148 A5JHN9 100049691
P OX26 Orexigenic neuropeptide QRFP complete Not Found F1S0X5 100524361
P PACA Pituitary adenylate cyclase-activating polypeptide complete Ssc.27598 P41535 414283
P PAHO Pancreatic polypeptide complete Ssc.456 P01300 397272
P PCSK1N Proprotein convertase subtilisin/kexin type 1 inhibitor complete Ssc.17429 Not Found 100621697
P PDGFA Platelet-derived growth factor alpha polypeptide complete Ssc.6173 F1RIZ0 100519764
P PDGFB Platelet-derived growth factor beta polypeptide complete Ssc.54182 P20034 100126843
P PDGFD Platelet-derived growth factor D complete Ssc.49835 F1SV50 100524161
P PDYN Proenkephalin-B complete Ssc.121 P01214 445529
P PENK Proenkephalin complete Ssc.11281 Q7M3H2/Q7M2Z7 100152093
P PNOC Prepronociceptin complete Ssc.15910 P55791 397257
P PROK2 Prokineticin 2 fragment EW633867 Not Found 100526076
P PRRP Prolactin-releasing peptide fragment Not Found Not Found Not Found
P PTHR Parathyroid hormone-related peptide complete Ssc.9991 Q866H2 396951
P PTHY Parathyroid hormone complete Ssc.668 P01269 399502
P PYY Peptide YY complete Ssc.63650 P68005 445018
P REL1 Pro-relaxin 1 complete Ssc.162 P01348 396891
P REL3 Relaxin 3 complete Ssc.42647 Q8HY17 503836
P RES18 Regulated endocrine-specific protein 18 complete Ssc.49266 F1SR77 100154377
P RFRP Neuropeptide VF precursor complete Ssc.75350 C4P9W1 100302024
P SCG1 Secretogranin-1 complete Ssc.15718 Q9GLG4 397154
P SCG2 Secretogranin-2 complete Ssc.13645 Q5FZP5 497237
P SCG3 Secretogranin-3 complete Ssc.6770 F1RYP7 100154760
P SECR Secretin complete Ssc.710 P63298 397464
P SLIB Somatoliberin complete Ssc.71374 P01287 100499556
P SMS Somatostatin complete Ssc.19520 P01168 494469
P SPXN Spexin complete Ssc.57764 F1SR03 100155886
P TIP39 Parathyroid hormone 2 complete Not Found F1RHZ 100515141
P TKN1 Tachykinin, precursor 1 complete Ssc.18075 F1SF85 100525179
P TKN4 Tachykinin-4 complete Ssc.23153 F1RTB7 100511101
P TKNK Tachykinin 3 complete Ssc.19565 P67934 492314
P TOR2X Torsin family 2, member A fragment Ssc.67158 B6VD08 100519815
P TRH Prothyroliberin complete Not Found P62968 100513309
P UCN1 Urocortin Traces Not Found F8R6K7 Not Found
P UCN2 Urocortin 2 complete Not Found F1SKM2 100521865
P UCN3 Urocortin 3 complete Not Found F1RYW0 100737810
P UTS2 Urotensin 2 complete Ssc.437 Q95J46 397268
P UTS2B Urotensin II-related peptide complete Not Found F1SFH3 100626084
P VEGFC Vascular endothelial growth factor C complete Ssc.12790 F1RT19 100525960
P VEGFD Vascular endothelial growth factor D complete Ssc.29289 F1SQU4 100155670
P VGF Neurosecretory protein VGF fragment Ssc.90772 Not Found 100624333
P VIP Vasoactive intestinal peptide complete Ssc.47759 E0Y441 100500718
C 7B2 Neuroendocrine protein 7B2 (secretogranin 5) complete Ssc.155 P01165 397110
C FURIN Furin complete Ssc.94009 F1RMJ1 100156882
C PCSK1 Proprotein convertase subtilisin/kexin type 1 PC1/3 complete Ssc.92884 Q28959 397103
C PCSK2 Proprotein convertase subtilisin/kexin type 2 complete Ssc.109 Q03333 445533
C PCSK4 Proprotein convertase subtilisin/kexin type 4 complete Ssc.47037 Not Found 100626523
C PCSK5 Proprotein convertase subtilisin/kexin type 5 incomplete Ssc.43614 Not Found 100519237
C PCSK6 Proprotein convertase subtilisin/kexin type 6 incomplete Ssc.73551 F1RZ92 100152144
C PCSK7 Proprotein convertase subtilisin/kexin type 7 complete Ssc.5628 F1SJT0 100523009
C PCSK9 Proprotein convertase subtilisin/kexin type 9 complete Ssc.84357 Not Found 100620501

a P: prohormone gene, C: prohormone convertase gene.

b Genome sequence found: complete or incomplete in the pig genome assembly, found in the Traces archive, or Not Found in any genome repository.

c,d,e Identifiers in the UniGene, UniProt and Gene databases.

Porter et al.

Porter et al. BMC Genomics 2012 13:582   doi:10.1186/1471-2164-13-582

Open Data