Additional file 1.

Analysis of rstR promoter regions. (A) Comparison of the rstR-rstA intergenic region of V. cholerae O395 classical O1 serotype and V. cholerae O1 biovar El Tor str. N16961. Predicted (O395) and known (N16961) promoter elements (-35 and -10) are highlighted in grey. Known (N16961, [72]) and predicted (O395) half-site operator sequences are highlighted in orange. Known (N16961) and predicted (O395) LexA-binding sites are shown in bold blue and underlined. RstR operators [36] are indicated by green boxes. (B) Alignment of 9 representative V. cholerae rstR-rstA intergenic regions. The LexA-binding site is shown in a blue box. The alignment shows a clear-cut distinction between El Tor and classical biotypes, but remarkably little divergence within each group, consistent with a recent dissemination of these phages. Sequence alignment was carried out using CLUSTALW [94] and default parameters. Adobe Portable Document File.

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Sanchez-Alberola et al. BMC Genomics 2012 13:58   doi:10.1186/1471-2164-13-58