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The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety

Mariya Gonik12, Elisabeth Frank1, Melanie S Keßler1, Darina Czamara1, Mirjam Bunck1, Yi-Chun Yen1, Benno Pütz1, Florian Holsboer1, Thomas Bettecken1, Rainer Landgraf1, Bertram Müller-Myhsok1, Chadi Touma1 and Ludwig Czibere1*

Author Affiliations

1 Max Planck Institute of Psychiatry, Munich, Germany

2 Current address: Institute for Stroke and Dementia Research, Ludwig Maximilian University, Munich, Germany

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BMC Genomics 2012, 13:579  doi:10.1186/1471-2164-13-579

Published: 31 October 2012

Additional files

Additional file 1:

Table S1. Single-nucleotide polymorphisms (SNP) tested using the custom designed oligo pool (Illumina). Custom designed SNP pool for Illumina Golden Gate Assays to genotype the F2 mice for the current study. Source (1) refers to SNPs, chosen from the Mouse Medium Density Linkage Panel, (2) additional SNPs selected from the MGI database based on genes known from previously published or unpublished studies. Gene association is assumed, if a SNP is located 10 kbp around a gene locus.

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Additional file 2:

Figure S1. Effect of prior tail-suspension test exposure on the behaviour in the open field test. Key parameters assessed in the open field test showed no significant difference in CD-1 mice between control (N = 10, only exposed to the open field test) and tst (N = 9, exposed to the tail-suspension test 48 h before the open field test) mice. Data are shown as means +SEM.

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