Table 2

Overlaps (%) of EIs with chromatin marksa
EIs overlap with Observed Random within LOCKs Fold enrichedc P valueb Random at WG Fold enrichedc P valueb
HAEC CTCF 61.3 4.4 13.9 <10-3 7.5 8.2 <10-3
DHSs 48.9 10.1 4.8 <10-3 7.5 6.5 <10-3
H3K4me3 23.3 6.8 3.4 <10-3 5.6 4.2 <10-3
H3K27me3 46.0 34.1 1.4 <10-3 27.8 1.7 <10-3
H3K36me3 20.0 14.1 1.4 <10-3 9.7 2.1 <10-3
H3K9ac 17.7 6.0 2.9 <10-3 5.3 3.3 <10-3
H1 CTCF 46.9 9.0 5.2 <10-3 11.8 4.0 <10-3
DHSs 36.0 7.1 5.1 <10-3 18.1 2.0 <10-3
H3K4me3 13.2 1.8 7.4 <10-3 1.4 9.8 <10-3
H3K27me3 21.6 10.8 2.0 <10-3 9.8 2.2 <10-3
H3K36me3 11.0 16.1 0.7 1 15.2 0.7 1
H3K9ac 28.9 11.8 2.4 <10-3 11.5 2.5 <10-3
HPF CTCF 56.9 7.9 7.2 <10-3 9.6 5.9 <10-3
DHSs 71.0 27.7 2.6 <10-3 19.2 3.7 <10-3
H3K4me3 30.8 8.1 3.8 <10-3 13.0 2.4 <10-3
H3K27me3 53.1 34.2 1.6 <10-3 29.0 1.8 <10-3
H3K36me3 22.6 16.5 1.4 <10-3 24.9 0.9 0.85
H3K9ac 13.2 2.5 5.2 <10-3 6.2 2.1 <10-3

a EIs of HAEC, H1 and HPF were compared with chromatin marks of HUVEC, H1 and normal lung fibroblasts, respectively (ref.10).

bP values were calculated by 1000 permutations.

cEnrichment is calculated as the ratio of observed to random.

Wen et al.

Wen et al. BMC Genomics 2012 13:566   doi:10.1186/1471-2164-13-566

Open Data