Figure 3.

Heat map comparing the SigB regulons of 19 Bc sensu lato genomes. This heat map is color-coded as: Red, gene absent from the genome; Blue, gene present in the genome, but lacking a SigB promoter binding site 5’ to the beginning of the predicted TU; Green, gene present in the genome and in a TU predicted to be controlled by a SigB promoter. Cluster analysis (tree shown on top of heat map) segregated these genes into 7 clusters, and we operationally divided two of these clusters (3 and 4) into subdivisions (a and b). This was done to emphasize that clusters 3a, 4a and 4b appear to contribute to functional differences between these organisms, while cluster 4b does not (see text for explanation). Cluster analysis also indicated that the genomes included in this figure could be assigned to one of four clades, designated A-D, as noted at the one end of the heat map; at the other end, the identity of each genome used in these analyses is listed. This information is summarized in Table 2. The orthologous cluster ID tags for the genes that are predicted to be in these SigB regulons are displayed across the bottom of the heat map. The genome annotations and cluster ID tags are legible in Additional file 1: Figure S1, and are cataloged in Additional file 2: Table S1.