Table 1

Clinical characteristics of study participants and their corresponding biological samples
Number Sex Age Disease** HBV DNA (copies/mL) Tissue weight (mg)
Pool* Samples Sample Pool
1 1 male 30 CHB 4.5 × 105 16.8 42.1
2 male 27 CHB 5.7 × 106 16.0
3 male 31 CHB 4.2 × 106 9.3
2 4 male 21 CHB 3 × 105 17.0 43.6
5 male 34 CHB 7.5 × 105 12.1
6 male 25 CHB 3.2 × 106 14.5
3 7 male 40 CHB 3 × 104 14.3 42.1
8 male 39 CHB 8.3 × 105 14.8
9 male 35 CHB 1.34 × 106 13.0
4 10 female 43 CHB 3.6 × 105 10.9 48.6
11 female 45 CHB 3.7 × 107 17.8
12 female 40 CHB 6.9 × 107 9.7
13 female 41 CHB 4.2 × 106 10.2
5 14 male 31 control undetected 81.0 176.0
15 male 30 control undetected 50.0
16 male 25 control undetected 45.0

* Liver biopsy samples from three to four individuals were pooled into a single specimen for ChIP-on-chip and ChIP-qPCR analyses.

** CHB, chronic hepatitis B. The serum HBV markers used for diagnosis were: HBsAg(+), HBsAb(−), HBeAg(+), HBeAb(−), and anti-HBc(+). Healthy controls were confirmed as: HBsAg(−), HBsAb(−), HBeAg(−), HBeAb(−), and anti-HBc(−).

Guo et al.

Guo et al. BMC Genomics 2012 13:563   doi:10.1186/1471-2164-13-563

Open Data