Additional file 5.
Figure S4. Bidirectional modulation of miR-107 expression. Panel A shows enriched KEGG pathways from predicted miR-107 target genes. Panel B shows the modulation of miR-107 expression levels in HEK-293 and HeLa cell types, indicative of miR-107 over-expression and inhibition. Panel C illustrates enriched KEGG pathways from modulated mRNA subsequent to miR-107 over-expression in HEK-293 and HeLa cell models. Panel D illustrates enriched KEGG pathways from modulated mRNA subsequent to miR-107 inhibition in HEK-293 and HeLa cell models. Panel E shows Venn diagrams and subsequent KEGG pathways analyses for the intersection of bidirectionally modulated genes in each cell type; and for the union of modulated genes across multiple cell models. The intersection of bidirectionally-modulated genes identifies genes modulated by both miR-107 over-expression and inhibition in each cell type. Genes modulated by either over-expression or inhibition were considered for the union of modulated genes across multiple cell types. The subsequent KEGG pathways analyses on these genes of interest revealed significantly enriched pathways, as evident in the bottom half of this panel. R-M: Receptor-mediated. RI: receptor interaction. ECM: Extracellular matrix. ARVC: Arrhythmogenic right ventricular cardiomyopathy.
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Carroll et al. BMC Genomics 2012 13:561 doi:10.1186/1471-2164-13-561