Additional file 4.

Figure S3. Distribution of predicted miRNA and E2F1 function for modulated mRNA. Panel A shows the proportion of modulated genes that can be attributed to predicted miR-181b and E2F1 function across individual and multiple cell models; whilst Panel B shows this for miR-107 predicted function. In both panels data is presented for canonical (negative miRNA-mRNA correlation) and non-canonical (positive miRNA-mRNA correlation) patterns of correlation. Differentially expressed genes are classified as being predicted in preferential fashion by: Targetscan conserved predicted miR-181b target; Targetscan non-conserved predicted miR-181b target, with PCT (probability of conservation) scores <0.1; Targetscan non-conserved predicted miR-181b target, with PCT scores >0.1; not predicted as a miR-181b target by Targetscan, but predicted by the miRGen algorithm; predicted as containing E2F1 recognition signatures using the TRANSFAC algorithm.

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Carroll et al. BMC Genomics 2012 13:561   doi:10.1186/1471-2164-13-561