Table 5

Comparison of metabolic key enzymes: PPP, pyruvate metabolism and TCA cycle.

PPP

Pyruvate Metabolism

TCA Cycle

GPD

6PGD

6PGL

PEPC

ME

PPS

PEPK

PDH

CS

ACO

ICD

STK

SDH

FH

MDH

MQO


Aca11017

••

••

• • ••

-

••

••

••

-

• • (•)

-

Cyn51142

• • •

••

••

• • (•)

-

Cyn8801

• • •

••

••

• • (•)

-

Glo7421

••

••

-

• • ••

••

-

• • •

(•)

-

Mic843

• • •

••

••

• • (•)

-

Nos7120

• • • • •

-

••

••

• • (•)

-

ProMed4

-

-

-

• • •

-

-

-

Pro9211

-

-

-

••

-

-

-

Pro9215

-

-

-

••

-

-

SycJA23

-

••

-

• • •

-

Syc7002

-

••

••

• • (•)

(•)

-

Syc7803

-

-

-

••

-

-

-

Syc7942

-

••

-

• • •

-

-

Syn6803

-

••

••

• • •(•)

-

ThermoBP1

••

-

••

-

• • •

-

-

Trich101

• • •

-

••

••

• • •

-

-


A summary of the genes involved in central carbon metabolism: The pentose phosphate pathway (PPP), pyruvate metabolism and the TCA cycle. Black dots represent the number of genes assiated with CLOGs assigned to the respective enzymatic function. The table does not distinguigh between individual CLOGs assigned to the same enzymatic function. Brackets indicate genes that are annotated with a different function as the respective CLOGs they are assigned to. These cases may represent erroneous annotation or bifunctional enzymes. Abbreviations are: GPD G6P dehydrogenase (1.1.1.49), 6PGD Phosphogluconate dehydrogenase (1.1.1.44), 6PGL Phosphogluconolactonase (3.1.1.31), PEPC PEP carboxylase (4.1.1.31), ME Malic enzyme (1.1.1.38), PPS Pyruvate water dikinase (2.7.9.2), PEPK PEP carboxykinase (4.1.1.49), PDH Pyruvate dehydrogenase (1.2.4.1), CS Citrate synthase (2.3.3.1), ACO Aconitase (4.2.1.3), ICD Isocitrate dehydrogenase (1.1.1.41/2), STK Succinate thiokinase (6.2.1.5), SDH Succinate dehydrogenase (1.3.99.1), FH Fumarate hydratase (4.2.1.2), MDH Malate dehydrogenase (1.1.1.37) and MQO Malate:Quinone oxidoreductase (1.1.5.4).

Beck et al. BMC Genomics 2012 13:56   doi:10.1186/1471-2164-13-56

Open Data