Table 9

Description of the top six canonical pathways significantly modulated in liver tissue when comparing H to L animals
Ingenuity canonical pathways Genes
LPS/IL-1 Mediated Inhibition of RXR Function ABCG8,CYP2C9,CYP7A1,CYP2C19, CYP4A11,GSTO1
Arachidonic Acid Metabolism ALOX15,CYP2C9,CYP2C19,CYP4A11
Fatty Acid Metabolism CYP2C9,CYP2C19,SDS,CYP4A11
PXR/RXR Activation CYP2C9,CYP7A1,CYP2C19
Linoleic Acid Metabolism ALOX15,CYP2C9,CYP2C19
FXR/RXR Activation ABCG8,APOB,CYP7A1

Statistical significance of pathway modulation was calculated via a right-tailed Fisher’s Exact test in Ingenuity Pathway analysis and represented as –log (P value): -log values exceeding 1.30 were significant FDR <0.05.

Ramayo-Caldas et al.

Ramayo-Caldas et al. BMC Genomics 2012 13:547   doi:10.1186/1471-2164-13-547

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