Graphical representation of the three merged networks generated by IPA. Depicted is the result of merging the network 1 (lipid Metabolism, Small Molecule Biochemistry and Vitamin and Mineral Metabolism), network 2 (lipid Metabolism, Molecular Transport and Small Molecule Biochemistry) and network 3 (carbohydrate Metabolism, Lipid Metabolism and Molecular Transport). The overrepresented canonical pathways such as Arachidonic and Linoleic Acid metabolism, PPARα/RXRα and FXR/RXR Activation are overlaid onto the resulting network, to show which genes are directly involved in these significant processes. Genes and gene products are represented as nodes and the relationship among these is represented as a line. Red indicates Up-regulated and green Down-regulated expression of genes when comparing H to L groups.
Ramayo-Caldas et al. BMC Genomics 2012 13:547 doi:10.1186/1471-2164-13-547