Paired genes exhibit a tighter transcriptional coordination during the budding yeast stress response. The average PCC was determined by bootstrapping random pairings of genes from the RRB and RP gene sets during a heat-shock (A and B), during the hyper-osmotic shock (C and D), and following treatment with menadione (E and F). The actual average PCC for the unpaired genes is indicated by *, for the paired but not adjacent genes by ·, and the adjacent paired genes by #.
Arnone et al. BMC Genomics 2012 13:546 doi:10.1186/1471-2164-13-546