|Most significant affected IPA canonical pathways|
|Canonical pathway (IPA)||Genes||P-value||Ratio|
|MIF-mediated Glucocorticoid Regulation||TLR4, NFKBIA, CD14, PTGS2, NFKBIB, NFKB1||4.67E-06||6/41|
|MIF Regulation of Innate Immunity||TLR4, NFKBIA, CD14, PTGS2, NFKBIB, NFKB1||1.8E-05||6/49|
|NF-κB Signalling||TLR4, IL1A, TGFBR1, RIPK1, NFKBIA, MYD88, BMP2, RELB, TNFAIP3, NFKBIB, NFKB1||2.46E-05||11/176|
|IL-10 Signalling||IL18RAP, IL1A, NFKBIA, CD14, ARG2, NFKBIB, NFKB1||4.47E-05||7/78|
|Hypoxia Signalling in the Cardiovascular System||HSP90B1, UBE2H (includes EG:7328), NFKBIA, UBE2B, HIF1A, NFKBIB, UBE2L6||5.4E-05||7/71|
|Production of Nitric Oxide and Reactive Oxygen Species in Macrophages||TLR4, PPP1R3D, NFKBIA, ARG2, NCF4, NFKB1, RHOH, IRF1, SIRPA||1.98E-06||9/189|
|LXR/RXR Activation||TLR4, IL18RAP, FASN, CD14, ARG2, NFKB1||1.85E-05||6/93|
|Toll-like Receptor Signalling||TLR4, NFKBIA, MYD88, CD14, NFKB1||2.72E-05||5/55|
|Acute Phase Response Signalling||SOD2, C3, NFKBIA, MYD88, OSM, SERPINA1, NFKB1, SAA1||3.59E-05||8/183|
|MIF-mediated Glucocorticoid Regulation||TLR4, NFKBIA, CD14, NFKB1||8.09E-05||4/41|
Five most significant canonical pathways identified with IPA using the significantly affected genes for T4 and T5. The identified canonical pathways are listed from the lowest to the highest p-value, and are reported with the involved genes and the corresponding ratio (# of genes involved/ # of known genes in the pathway).
Cremonesi et al.
Cremonesi et al. BMC Genomics 2012 13:540 doi:10.1186/1471-2164-13-540