Table 1

Top 25 genes co-expressed with aging related genes
Gene Previous association evidence Reference
Thbs1 Plays a role in platelet aggregation, angiogenesis and tumorigenesis [57-59]
Ctsh No previous associations
2310043n10rik No previous associations
Sat1 Induction has been suggested as a therapeutic strategy for treating colorectal cancer [60]
Tcn2 No previous associations
Pgcp No previous associations
D12ertd647e No previous associations
Cd74 Initiates signalling leading to cell proliferation and survival [61]
B2m B2m deficient mice suffer from tissue iron overload [62]
Tgm2 Overexpression increases apoptosis in neuroblastoma cells [63]
Implicated in fibrosis, neurodegenerative and celiac disease [64]
Rarres2 No previous associations
Anxa1 Plays an important role in anti-inflammatory signalling, apoptosis and proliferation [65,66]
Il10rb No previous associations
Ctsc Mutations cause Papillon-Lefevre Disease [67,68]
Lipa Mutations can cause Cholesteryl ester storage disease and Wolman disease [69]
IL3ra1 No previous associations
Lgals3bp Associated with cancer and metastasis [70]
Pros1 Associated with Thrombosis [71,72]
Fcgr2b No previous associations
Scd1 Plays an important role in body weight regulation and development of obesity [73]
Ifi35 No previous associations
Ctla2b No previous associations
Cebpd Implicated in adipocyte differentiation, learning and memory, mammary epithelial cell growth control. [74-76]
Loss of Cebpd leads to chromosome instability [77]
Fcgrt No previous associations
H2-t23 No previous associations

For a full list refer to Additional file 3.

van Dam et al.

van Dam et al. BMC Genomics 2012 13:535   doi:10.1186/1471-2164-13-535

Open Data