Table 2

Regulation of key metabolic pathways in guinea pig lungs infected with M. tuberculosis
Pathway Up Down
Oxidative Phosphorylation NDUFA12, NDUFV1, UQCRC2, SDHB, NDUFAB1, ATP5C1, PPA1, ATP6V0E1, ATP5J, NDUFB8, ATP5A1, NDUFA7, COX5A, LHPP, UQCRC1, ATP5G3, NDUFA11, ATP5J2, NDUFV3, NDUFV2, NDUFS6, NDUFS8, NDUFS3, ATP6V1D, COX5B, COX6A2, COX4I1, ATP6V1F, ATP6V0D1, COX7A2L, ATP6V0C, ATP6V1E1, ATP6V0B, ATP6V1B2, NDUFB4, NDUFB2, NDUFA3, COX17 ATP5O, ATP5F1, ATP12A, NDUFB5, NDUFB7, NDUFA4
Glycolysis/Gluconeogenesis LDHA, ENO1, HK1, ADH5, TPI1, GAPDH, ADH1A, AKR1A1, ALDOA, PGK2, ENO3, GPI ALDOC, DLAT, PFKL
TCA cycle FH, SDHB, PC, MDH2, IDH1, ACO2, SUCLG1 DLAT
Lipid, Glycerolipid and Glycerophospholipid metabolism ABHD2, ABHD8, ACSL5, ADH1A, ADH5, AGPAT2, AKR1A1, CPT2, CEPT1, CYP27A1, CYP2B18A, CYP26B1, DGKA, FDPS, GCDH, HADHA, HADHB, LPL, PLA2G2A, PGS1 AGPAT1, AGPAT3, ACSL1, CPT1B, CYP2F1, CYP2A13, CYP1A2, CYP11A1, CYP2D40, PLD2, PPAP2A, PLA2G2C, PLA2G5, PAFAH1B1, PNPLA3, PTDSS2, LPGAT1
Purine and Pyrimidine metabolism ADSS, NT5C2, NPR2, AK2, XDH, ADCY4, POLR2E, HPRT1, PRP, DPYD, TXNRD2, NT5C2, CAD AK1, DCTD, POLA1, POLR2F, POLR2K, PRPS1L1, GUK1, PDE6G, PDE6A, POLR3GL, ENPP1, ZNRD1, PRUNE, TYMS, TK1
Amino acid metabolism GLUL, GCDH, HADHA, HADHB, PLOD3, TMLHE, SETD1A, SETD8, HSD17B10, IVD, LDHA, MIF, PRDX6 ALDH4A1, ALDH6A1, ASS1, AMT, AGXT, AGMAT, ABAT, AHCYL1, CYP1A2, CKB, DNMT1, DBT, DDC, GLS, GLUD1, GLDC, GNMT, HMGCS1, NOS1, MAT2A, ODC1, WHSC1L1, SUV420H2, SUV420H1

Jain et al.

Jain et al. BMC Genomics 2012 13:520   doi:10.1186/1471-2164-13-520

Open Data