A putative AED event. A) Multiple sequence alignment of hepatoma-derived growth factor (HDGF) and HDGF-like proteins. Black lines indicate the two main subgroups corresponding to the duplication node in the phylogenetic tree. Known phosphorylation sites are labeled with asterisks. B) The phylogenetic tree constructed using the Neighbour-Joining algorithm with 500 bootstraps. Bootstrap values for each node are shown in red. The distance between human and mouse HDGF1 sequences (in blue) is longer than the distance between human HDGF1 and mouse HDGF sequences (in green).
Prosdocimi et al. BMC Genomics 2012 13:5 doi:10.1186/1471-2164-13-5