Table 1

Antagonistically linked traits
Disease Abbr. Antagonistically Linked Traits (Loci) #
CROHN DISEASE CD AST (17q12); T1D (1p13, 16p11); VIT (1p13); T2D (2p21); RA (1p13); SLE (1p13); PS (19p13); MS (17q21) 8
ASTHMA AST CD (17q12); UC (17q12); BLC (17q12); RA (17q12); PS (5q31) 5
GLIOMA GLI COR (9p21); T2D (9p21); GLA (9p21); IPF (5p15) ; TN (5p15) 5
ARTHRITIS, RHEUMATOID RA AST (17q12); MS (20q13); CD (1p13) 3
MULTIPLE SCLEROSIS MS RA (20q13); HCC (1p36); CD (17q21) 3
COLITIS, ULCERATIVE UC AST (17q12); CeD (1p36); SLE (1q23) 3
LUNG NEOPLASMS LN PN (5p15); IPF (5p15); TN (5p15) 3
TESTICULAR NEOPLASMS TN GLI (5p15); LN (5p15) 2
VITILIGO VIT CD (1p13); MEL (11q14) 2
DIABETES MELLITUS, TYPE 1 T1D CD (1p13, 16p11); IBD (1p13) 2
DIABETES MELLITUS, TYPE 2 T2D GLI (9p21); CD (2p21) 2
CELIAC DISEASE CeD UC (1p36); CRC (3q26) 2
IDIOPATHIC PULMONARY FIBROSIS IPF GLI (5p15); LN (5p15) 2
PSORIASIS PS AST (5q31); CD (19p13) 2
LUPUS ERYTHEMATOSUS, SYSTEMIC SLE CD (1p13); UC (1q23) 2
GLAUCOMA GLA GLI (9p21) 1
MELANOMA MEL VIT (11q14) 1
PANCREATIC NEOPLASMS PN LN (5p15) 1
ALCOHOLISM ALC HNN (12q24) 1
COLORECTAL NEOPLASMS CRC CeD (3q26) 1
INFLAMMATORY BOWEL DISEASES IBD T1D (16p11) 1
CARCINOMA, HEPATOCELLULAR HCC MS (1p36) 1
LIVER CIRRHOSIS, BILIARY BLC AST (17q12) 1
CORONARY DISEASE COR GLI (9p21) 1
HEAD AND NECK NEOPLASMS HNN ALC (12q24) 1

Listed are diseases and the traits that share an antagonistic variant with the respective disorder. In the first column the considered disease is given. The second column specifies the abbreviation of the disorder in the first column. The third column contains the abbreviated diseases as defined in column two which have an antagonistic link to the disorder in column one, followed by the chromosomal location of the antagonistically associated variant(s) in parentheses. The last column lists the count of traits antagonistically linked to the disorder in column one. For a more detailed listing see Additional file 2: Table S1.

Arnold et al.

Arnold et al. BMC Genomics 2012 13:490   doi:10.1186/1471-2164-13-490

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