Resolution:
## Figure 3.
Clustering of diseases with respect to genetic signals. We applied complete-linkage hierarchical clustering to identify groups of traits
which show homogeneous patterns of genetic overlap to other disorders. We calculated
for each pair of diseases the Pearson correlation of the patterns of overlap to the
other diseases. The correlation values are ranging from âˆ’1 (white) indicating complete
negative correlation to +1 (black) reflecting a perfect positive correlation. As the
minimal value of the correlation coefficient wasâ€‰>â€‰âˆ’0.1, we collapsed the range of
negative correlation. In red numbers, the 15 disease clusters are denoted. The Euclidian
distance threshold was chosen as the maximal distance at which the six diseases showing
no or only weak correlation with any other disease (disease names in gray) remain
non-clustered.
Arnold |