Figure 3.

Clustering of diseases with respect to genetic signals. We applied complete-linkage hierarchical clustering to identify groups of traits which show homogeneous patterns of genetic overlap to other disorders. We calculated for each pair of diseases the Pearson correlation of the patterns of overlap to the other diseases. The correlation values are ranging from −1 (white) indicating complete negative correlation to +1 (black) reflecting a perfect positive correlation. As the minimal value of the correlation coefficient was > −0.1, we collapsed the range of negative correlation. In red numbers, the 15 disease clusters are denoted. The Euclidian distance threshold was chosen as the maximal distance at which the six diseases showing no or only weak correlation with any other disease (disease names in gray) remain non-clustered.