A transcriptional signature identifies the stages of neurodegeneration or neuroprotection in homozygous sall mutant embryos. (A) The groups of genes significantly over- or underrepresented in each stage are indicated with arrows oriented up- or downwards, respectively. Black arrows indicate genes putatively associated with neuroprotection, while white arrows represent those groups putatively associated with neurodegeneration. Big arrows symbolize groups of genes significantly represented with p < 0.001 and small arrows groups significantly represented with p < 0.05. Neurodegeneration of homozygous sall mutants at stage 16 coincides with the upregulation of genes associated principally to the groups of Neurodegeneration, Redox, Lifespan/Aging and Starvation, and downregulation of other genes belonging to the Redox group, and genes from Mitochondrial diseases, Neuronal and Neuroprotection groups. The recovery of the neurodegenerative phenotype at stage 17 coincides with the upregulation of genes of the Immune response group, as well as genes from Mitochondrial diseases and Salt stress groups, and some from Lifespan/Aging, Starvation, and Neurodegeneration/Neuroprotection groups. This neurodegeneration reversal stage coincides also with the downregulation of genes belonging to the Redox group, and of other genes belonging to Neurodegeneration, Lifespan/Aging, Starvation and Neuronal groups. The two photos are reprinted from Cantera et al., 2002.
Ferreiro et al. BMC Genomics 2012 13:483 doi:10.1186/1471-2164-13-483