Figure 1.

Steps of the bioinformatics study. 1.1 - Phylogenetic alignment of ANT genes in various mammalian species to filter unusable sequences and identification of matrices shared by aligned mammalian sequences from each ANT isoform gene (via Genomatix FrameWorker tool); 1.2 identification of TFBS in each human ANT isoform gene (MatInspector tool); 2 - Construction of regulation models by combining the selected matrices TFBS, IUPAC strings from bibliography; 3 - location of models in the whole human genome (3.1), in the ElDorado promoter database (3.2), and search for genes with models conserved in orthologous promoters (3.3); 4 - Identification of potentially co-regulated genes by GeneProm analysis.

Dupont et al. BMC Genomics 2012 13:482   doi:10.1186/1471-2164-13-482
Download authors' original image