Table 3

KEGG pathway analysis for those genes whose mRNA expression was significantly associated with miRNA expression (p < 0.05)
    miRNA
Correlated genes (n = 17208) SIGNIFICANTLY ENHANCED KEGG PATHWAYS (4 gene threshold)
p < 0.05 q < 0.2 KEGG Pathway name (observe, expected, p-value)
    miR-15b
541 1 Focal adhesion (o = 10; e = 1.8; p = 2.8e-5)
Regulation of actin cytoskeleton (o = 10; e = 1.9; p = 4.2e-5)
Long-term potentiation (o = 5; e = 0.6; p = 6.3e-4)
Pancreatic cancer (o = 4; e = 0.7; p = 7.1e-3)
Long-term depression (o = 4; e = 0.7; p = 7.7e-3)
Axon guidance (o = 4; e = 1.3; p = 4.0e-2)
    miR-212
858 0 MAPK signaling pathway (o = 12; e = 3.8; p = 7.1e-4)
Regulation og actin cytoskeleton (o = 10; e = 2.8; p = 7.4e-4)
Calcium signaling pathway (o = 8; e = 2.4; p = 4.5e-3)
Tight junction (o = 8; e = 1.6; p = 3.2e-4)
    miR-34c
532 0 MAPK signaling pathway (o = 12; e = 2.7; p = 3.3e-5)
Jak-STAT signaling pathway (o = 7; e = 1.5; p = 9.9e-4)
Focal adhesion (o = 7; e = 1.9; p = 3.6e-3)
Long-term depresion (o = 4; e = 0.7; p = 8.4e-3)
    miR-31
586 0 Regulation of actin cytoskeleton (o = 11; e = 2.1; p = 1.5e-5)
MAPK signaling pathway (o = 10; e = 2.9; p = 8.5e-4)
Axon guidance (o = 9; e = 1.3; p = 1.5e-5)
GnRH signaling pathway (o = 7; e = 1.0; p = 1.0e-4)
Wnt signaling pathway (o = 6; e = 1.5; p = 5.5e-3)
    miR-301a
927 0 Focal adhesion (o = 13; e = 3.1; p = 2.5e-5)
Regulation of actin cytoskeleton (o = 11; e = 3.2; p = 6.0e-4)
MAPK signaling pathway (o = 10; e = 4.4; p = 1.6e-2)
Colorectal cancer (o = 7; e = 1.4; p = 6.5e-4)
Long-term potentiation (o = 4; e = 1.1; p = 2.5e-2)

Parsons et al.

Parsons et al. BMC Genomics 2012 13:476   doi:10.1186/1471-2164-13-476

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