Table 2

Pathway enrichment in the PP01 psoriatic group
Pathway name p-value q-value
Cluster1
NOTCH1 Intracellular Domain Regulates Transcription 0.0008 0.0227
Signaling by NOTCH1 0.0017 0.0254
Signaling by NOTCH 0.0028 0.0275
NOTCH1 Intracellular Domain Regulates Transcription 0.0007 0.0227
Cluster2
Urea cycle 0.0066 0.0187
Synthesis of very long-chain fatty acyl-CoAs 0.0104 0.0187
Fatty Acyl-CoA Biosynthesis 0.0133 0.0187
Triglyceride Biosynthesis 0.0271 0.0286
Cluster3
PI3K events in ERBB4 signaling 0.0003 0.0054
PI3K events in ERBB2 signaling 0.0004 0.0054
Signaling by ERBB4 0.0019 0.0142
Signaling by ERBB2 0.0024 0.0142
AKT phosphorylates targets in the nucleus 0.0059 0.0289
Signaling by TGF beta 0.0106 0.0400
SHC1 events in ERBB4 signaling 0.0139 0.0400
GRB2 events in ERBB2 signaling 0.0152 0.0400
Signaling by BMP 0.0159 0.0400
SHC1 events in ERBB2 signaling 0.0165 0.0400
PIP3 activates AKT signaling 0.0205 0.0434
Immune System 0.0215 0.0434
PI3K/AKT activation 0.0263 0.0447
Nuclear signaling by ERBB4 0.0273 0.0447
GAB1 signalosome 0.0283 0.0447
Interleukin-1 signaling 0.0296 0.0447

Ainali et al.

Ainali et al. BMC Genomics 2012 13:472   doi:10.1186/1471-2164-13-472

Open Data