Figure 4.

A multidimensional scaling (MDS) plot to illustrate the molecular grouping of samples. A dissimilarity matrix in random forest is constructed through the use of synthetic data drawn from the distribution of psoriatic samples (see Methods). Patients are clustered according to these dissimilarities and two distinct psoriatic groups are identified, PP01 (green) and PP02 (purple). All lesional samples (PP) cluster away from both normal (NN) and non-lesional (PN) tissue samples, in accordance to observations in figure 2c.