Table 1

Expression probes associated with 17q21.31 inversion region in different datasets
Whole blood
Probe ID t B (95% CI) p
LRRC37A4 ILMN_2393693 18.29 0.37 (0.33, 0.41) 1.4 x 10-55
MGC57346 ILMN_1784428 −8.63 −0.19 (−0.24, -0.15) 1.2 x 10-16
PLEKHM1 ILMN_1709549 ns ns ns
MAPT dt dt dt dt
LRRC37A ILMN_1783673 ns ns ns
CRHR1 ILMN_1732426 ns ns ns
Cerebellum
Probe ID t B (95% CI) p
LRRC37A4 n/a n/a n/a n/a
MGC57346 n/a n/a n/a n/a
PLEKHM1 ILMN_1709549 4.98 0.18 (0.11, 0.25) 1.9 x 10-6
MAPT ILMN_1710903 6.01 0.36 (0.24, 0.48) 1.6 x 10-8
LRRC37A ILMN_1783673 ns ns ns
CRHR1 ILMN_1753706 −4.18 −0.09 (−0.13, -0.05) 5.2 x 10-5
Frontal Cortex
Probe ID t B (95% CI) p
LRRC37A4 n/a n/a n/a n/a
MGC57346 n/a n/a n/a n/a
PLEKHM1 ILMN_1709549 ns ns ns
MAPT ILMN_1710903 4.76 0.34 (0.20, 0.48) 4.8 x 10-6
LRRC37A ILMN_1783673 −7.92 −0.25 (−0.32, -0.19) 7.4 x 10-13
CRHR1 ILMN_1753706 dt dt dt
Temporal Cortex
Probe ID t B (95% CI) p
LRRC37A4 n/a n/a n/a n/a
MGC57346 n/a n/a n/a n/a
PLEKHM1 ILMN_1709549 n/a ns ns
MAPT ILMN_1710903 ns ns ns
LRRC37A ILMN_1783673 −9.15 −0.29 (−0.35, -0.23) 6.9 x 10-16
CRHR1 ILMN_1753706 dt dt dt
Pons
Probe ID t B (95% CI) p
LRRC37A4 n/a n/a n/a n/a
MGC57346 n/a n/a n/a n/a
PLEKHM1 ILMN_1709549 ns ns ns
MAPT ILMN_1710903 ns ns ns
LRRC37A ILMN_1783673 −6.03 −0.17 (−0.23, -0.12) 1.5 x 10-8
CRHR1 ILMN_1753706 dt dt dt

The genes found to be associated to the 17q21.31 inversion haplotypes are listed in the first column with their corresponding probe IDs (Illumina H12.v3 in blood and Illumina H8.v2 in brain). The genes have been tested in two datasets and results of linear regression are given, t, B (with 95% CI) and p-values. The B values indicate the actual change in expression associated with each copy of the H1 allele (0, 1 or 2). The corresponding unadjusted p-values are listed when significant. Not all genes were available or detected in each dataset; n/a = not available on array, dt = did not meet detection threshold in tissue, ns = not significant. All probes for the genes in the 17q21.31 region are listed in Additional file 1: Table S1.

de Jong et al.

de Jong et al. BMC Genomics 2012 13:458   doi:10.1186/1471-2164-13-458

Open Data