Table 2

Top 20 KEGG pathways based on gene number following PML knockdown
KEGG canonical pathway name Gene number Over-represent fold q value
Metabolic pathways 95 3.129177 2.67E-20
Pathways in cancer 39 4.257452 1.77E-12
Cell cycle 30 8.4032 1.78E-17
MAPK signaling pathway 27 3.600042 2.30E-07
Cytokine-cytokine receptor interaction 24 3.297377 4.66E-06
Focal adhesion 23 4.11424 2.30E-07
Regulation of actin cytoskeleton 23 3.847576 7.25E-07
Small cell lung cancer 20 8.4032 7.25E-12
Purine metabolism 20 4.723367 2.30E-07
Endocytosis 20 3.864573 3.69E-06
p53 signaling pathway 19 9.949875 1.71E-12
Pyrimidine metabolism 17 6.33272 3.70E-08
Tight junction 17 4.584133 3.09E-06
Natural killer cell mediated cytotoxicity 17 4.483751 3.65E-06
Chemokine signaling pathway 17 3.199343 0.000168
Cell adhesion molecules (CAMs) 15 4.044824 4.55E-05
Lysosome 14 4.398892 3.96E-05
Leukocyte transendothelial migration 14 4.25103 4.86E-05
Axon guidance 14 3.921493 0.000105
T cell receptor signaling pathway 13 4.349434 7.40E-05

Cheng and Kao

Cheng and Kao BMC Genomics 2012 13:453   doi:10.1186/1471-2164-13-453

Open Data