Figure 4.

The interactive effects of PML knockdown on TNFα signaling-induced inflammatory response. (a and b) Two clusters of genes annotated with inflammation-associated ontology information were identified in a clustering analysis of the log fold change values of significantly affected genes combined with their gene ontology information (GO and KEGG). The affected categories of ontology information and the Fisher exact test results are summarized in the table. “CT-CU”, TNFα effects with control siRNA transfection; “PT-PU”, TNFα effects with PML siRNAs transfected; “PU-CU”, PML knockdown effects; “PT-CT”, PML knockdown effects when TNFα treated; “PxT”, the interaction effects of PML knockdown and TNFα treatment defined as P×T = (PT−PU)−(CT−CU)=(PT−CT)−(PU−CU). GO, Gene Ontology database; BP, biological function; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes.