PML function and TNFα signaling are linked to multiple human diseases. The significantly affected genes by PML knockdown and TNFα signaling are significantly associated (q < 0.01) with multiple human diseases analyzed as described in Methods using a Disease Ontology database. The diseases are sorted vertically according to the number of associated significantly altered genes following PML knockdown. The transformed values (−ln(qvalue)) of FDR adjusted p value for each category of diseases are shown in the same graph. The dashed lines indicate −ln(q = 0.01) ≈ 4.6.
Cheng and Kao BMC Genomics 2012 13:453 doi:10.1186/1471-2164-13-453