Open Access Research article

Genetic module and miRNome trait analyses reflect the distinct biological features of endothelial progenitor cells from different anatomic locations

Cheng-Chung Cheng1, Hung-Hao Lo2, Tse-Shun Huang2, Yi-Chieh Cheng2, Shi-Ting Chang3, Shing-Jyh Chang4 and Hsei-Wei Wang2356*

Author Affiliations

1 Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

2 Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan

3 Institute of Biomedical Informatics, National Yang-Ming University, No. 155, Sec 2, Li-Nong Street, Taipei, Taiwan

4 Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan

5 Department of Education and Medical Research, Taipei City Hospital, Taipei, Taiwan

6 National Yang-Ming University VGH Genome Research Center, National Yang-Ming University, Taipei, Taiwan

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BMC Genomics 2012, 13:447  doi:10.1186/1471-2164-13-447

Published: 3 September 2012

Additional files

Additional file 1 Figure S1:

Primers used in RT-qPCR validation.

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Additional file 2 Figure S2:

Gene expression signatures and functional modules of different EPCs.

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Additional file 3 Figure S3:

Distribution of CB-EPC cell cycle genes according to the KEGG database. CB-EPC genes are labeled with red stars. The P value is also shown.

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Additional file 4 Figure S4:

Over-expressing miR-31 in PB-EPC (A) or knocking down endogenous miR-31 in CB-EPC (B) did not affect cell proliferation rate at a significant level in the first 24 hours of transfection.

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Additional file 5 Figure S5::

Distribution of PB-EPC genes in the Wnt signaling pathway according to the KEGG database. PB-EPC genes are labeled with red stars.

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Additional file 6 Table S1:

Distribution of PB-EPC genes in the MAPK signaling pathway according to the KEGG database. PB-EPC genes are labeled with red stars.

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Additional file 7 Table S2:

Distribution of PB-EPC genes in the Wnt signaling pathway according to the IPA web tool. Involved PB-EPC genes are in green and indicated.

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