Table 3

Shared effects of fasting and insulin-neutralization on differential gene expression
Gene symbol Gene title Fold change Insu-Neu vs. Fed Fold change Fasting vs. Fed
Up-regulated genes
PDK4 pyruvate dehydrogenase kinase, isozyme 4 7.06 17.28
AOX1 aldehyde oxidase 1 2.94 6.66
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 2.41 2.77
FBXO8 F-box protein 8 2.09 4.15
AGTR1 angiotensin II receptor, type 1 2.04 4.15
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 1.99 2.25
PSME4 proteasome (prosome, macropain) activator subunit 4 1.97 3.86
ICA1 islet cell autoantigen 1, 69 kDa 1.85 2.8
IP6K2 inositol hexakisphosphate kinase 2 1.77 2.75
UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2 1.72 1.89
ACBD5 acyl-Coenzyme A binding domain containing 5 1.72 2.51
LOC417776 similar to hypothetical protein 1.62 1.84
CTSL2 cathepsin L2 1.54 2.09
ZNF217 zinc finger protein 217 1.54 2.6
IFNAR1 Interferon (alpha, beta and omega) receptor 1 1.52 3.47
Down-regulated genes
DGAT2 diacylglycerol O-acyltransferase homolog 2 (mouse) 6.1 10.5
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2.4 2.17
ANKRD9 ankyrin repeat domain 9 2.19 1.98
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex 1.95 1.76
PTP4A3 protein tyrosine phosphatase type IVA, member 3 1.8 2.3
HSPA5 heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) 1.76 1.74
NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs) 1.73 1.57
MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 1.71 2.2
GRAMD2 GRAM domain containing 2 1.69 2.37
DHDDS dehydrodolichyl diphosphate synthase 1.63 1.58
DYNLL2 dynein, light chain, LC8-type 2 1.6 2.52
CDT1 chromatin licensing and DNA replication factor 1 1.57 1.51
FAHD1 fumarylacetoacetate hydrolase domain containing 1 1.56 1.61
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 1.56 1.82
BTBD11 BTB (POZ) domain containing 11 1.55 1.71

FDR p-value <0.05.

Ji et al.

Ji et al. BMC Genomics 2012 13:441   doi:10.1186/1471-2164-13-441

Open Data