Contribution of individual SNPs to overall risk for (A) multiple sclerosis and (B) obesity. Single nucleotide polymorphisms (SNPs) with associations established from genome-wide association shown in decreasing order of number of studies showing association for a given SNP. An increasing shade of black filling squares corresponding to each SNP on the graph is indicative of the number of studies that reports a disease association for that SNP. The size of boxes is proportional to the logarithm of the number of samples used to calculate the likelihood ratio (LR). The post-test probabilities were computed using the pre-test estimate as a starting point. An updated combined post-test risk probability is shown along the y-axis that includes the contribution of indicated SNP and those above it on the graph. *Gene names are shown where the SNP lies in an annotated gene region. +Number of studies reporting an association. #Number of samples used to calculate the LR. GIH- The frequency of a SNP in the Gujarati Indian Population from the Varimed database is also shown.
Gupta et al. BMC Genomics 2012 13:440 doi:10.1186/1471-2164-13-440