Model for the generation of chimeric mRNAs. Induced by trans-acting factors, such as the CTCF, parental genes dynamically co-localise to the shared transcription factory. The same or similar transcription factors coordinate the transcription of parental genes. Then, the nascent transcripts are joined together and spliced.
Ma et al. BMC Genomics 2012 13:429 doi:10.1186/1471-2164-13-429