Table 3

Functional groups observed in up-regulated genes in virulent strains related to control strains after 15, 30 and 60 min of incubation in blooda
Functional groups Time (min) Genes
15 30 60
Base-excision repair + - - POL30, POL31, RAD27, APN1, OGG1
Vacuole organization + + - CMD1, VPS3, CUP5, VTC1, SFK1, VID24/ MD1/ VPS45/ TRX2/ TRX1/ VAC7/ TPM1/ VTC3/
Xenobiotic transporter + - - PDR5, SNQ2, PDR12
Amino acid biosynthetic process/ Amine biosynthetic process/ Nitrogen compound biosynthetic process - + + ARO4/ ARO3/ LYS4/ HIS1/ ARG5/ARG6/ SER3/ILV1/ SER33/ HIS5/ LYS1/ TRP3/ ARG1/ ARG8/ LEU9/ ORT1/ SAM4
Amino acid metabolic process - + + ADH5/ ARO4/ ARO3/ LYS4/ HIS1/ ARG5/ARG6/ SER3/ ILV1/ADH4/ SER33/ HIS5/ LYS1/ URA2/ TRP3/ MSE1/ ARG1/ ARG8/ LEU9/ ORT1/ SAM4/
Phosphatase activity - + + PTC3/ PHO3/ PHO5/ DPP1/ LPP1/ SDT1/ PHO12/ INP51/ SAP185/ SAC1/ PPZ1/ TSL1/ YMR087WTPS3/ FCP1/ YNL217W/ PHO12
Transmembrane transporter activity - + - CTP1/ GGC1/ ATP17/ GNP1/ PIC2/ HXT10/ VPS73/ ZRT1/ TPO2/ TNA1/ AVT1/ VMA5/ ZRT3/ YBT1/ AQY2/ SMF3/ ZRT2/ ATR1/ ITR2/ ORT1/ ODC2/ PDR12/ YMC1/ ANT1/ TPO3/
Cell redox homeostasis - - + TTR1/ TRX2/ TRX1/ TSA1/ GLR1/ YNL134C/ TPS1/ PGM2/ GRE2/ MXR1/ PDI1/ UBA1/ LYS20/ AHP1/ TKL1/TAL1/ ADH6/ CYS3

a Functional groups were (+) or were not (−) significantly overrepresented (p-values < 0.05).

Llopis et al.

Llopis et al. BMC Genomics 2012 13:419   doi:10.1186/1471-2164-13-419

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