Email updates

Keep up to date with the latest news and content from BMC Genomics and BioMed Central.

Open Access Highly Accessed Research article

Genomic variation in the vomeronasal receptor gene repertoires of inbred mice

Elizabeth H Wynn, Gabriela Sánchez-Andrade, Keren J Carss and Darren W Logan*

Author Affiliations

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

For all author emails, please log on.

BMC Genomics 2012, 13:415  doi:10.1186/1471-2164-13-415

Published: 21 August 2012

Additional files

Additional file 1:

Table S1. Listing the numbers of VRs at each stage of our parsing process, subdivided by receptor class.

Format: DOC Size: 33KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Table S2. Listing the SNP distribution in VR repertoires, subdivided by receptor class.

Format: DOC Size: 32KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 3:

Figure S1. Showing an example of a VR, Vmn2r100, deleted in SPRET/EiJ. (A) Exome sequencing of C3HeB/FeJ indicates the genomic location of the Vmn2r100 gene (black bars) in that strain, by the position of reads mapped to the C57BL/6J reference (blue lines). (B) The mapping of whole genome sequence reads from SPRET/EiJ to the same genomic interval shows a defined gap in read coverage. This is consistent with a genomic deletion in this strain. (C) The mapping of whole genome sequence reads from CAST/EiJ to the same genomic interval shows that reads span the whole region in this strain, and thus suggests the gap in SPRET/EiJ is not due to a read mapping problem.

Format: TIFF Size: 138KB Download file

Open Data

Additional file 4:

Figure S2. Showing evidence of a duplication in Vmn2r56 in the CAST/EiJ line. Sequence reads from CAST/EiJ are stacked vertically, mapped to an exon of Vmn2r56 on chromosome 7 of the C56BL/6J reference sequence (bottom, black text). SNPs are indicated in red, with three sites showing ambiguous calls (asterisks: sites where approximately half the reads has one nucleotide and the other half has a different nucleotide). The nucleotides at these sites co-segregate within reads (blue text and green text), consistent with two distinct sequences in CAST/EiJ mapping to the same location.

Format: TIFF Size: 627KB Download file

Open Data

Additional file 5:

Lists all the SNPs identified in V1Rs, subdivided by gene and strain.

Format: XLSX Size: 421KB Download file

Open Data

Additional file 6:

Lists all the SNPs identified in V2Rs, subdivided by gene and strain.

Format: XLSX Size: 611KB Download file

Open Data

Additional file 7:

Lists all the SNPs identified in FPRs, subdivided by gene and strain.

Format: XLSX Size: 24KB Download file

Open Data