Table 2

The effect of SNPs on miRNA precursors energy change
Precursor SNP position in precursor SNP SNP location △△G (kcal/mol)
s0008 19 A → C mature −0.3
s0027-1 53 U → G mature −1.4
s0008 39 C → G Stem 2.2
s0009 41 U → C Stem −0.5
s0015 48 C → A Stem 0.3
s0015 50 U → C Stem −1.3
s0027-1 52 G → U Stem 0.6
s0007 43 G → A Stem −0.1
mir-140 43 G → A Loop 0
s0007 39 A → C Loop 0
s0009 45 U → G Loop 0
s0013 40 C → U anti-stem 2.7
s0013 41 A → G anti-stem 1

MFE: minimum free energy.

ΔΔG: the MFE difference value between SNP-type precursors and wild-type precursors. The minus value indicated that the SNP-type precursors had lower structure energy than the wild precursors. Otherwise, the former had higher structure energy than the latter.

Zhu et al.

Zhu et al. BMC Genomics 2012 13:413   doi:10.1186/1471-2164-13-413

Open Data